Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.

Journal article

Soluble tumour necrosis factor receptors (sTNF-R) are up-regulated at sites of chronic inflammation such as rheumatoid synovial joints. The p75 sTNF-R is the more abundant, suggesting an important role for this TNF inhibitor in regulating TNF bioactivity in vivo. As the precise cellular source of these soluble receptors is not known, we investigated the production and regulation of sTNF-R by T lymphocytes, an abundant cell type in inflammatory infiltrates, which upon activation express high l...

Expand abstract

Authors: Cope, A; Aderka, D; Wallach, D; Kahan, M; Chu, N

• Publication status: Published
• Journal: Immunology
• Volume: 84
• Issue: 1
• Pages: 21-30
• Publication date: 1995-01-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Kinetics; Flow Cytometry; Receptors, Tumor Necrosis Factor; Humans; T-Lymphocytes; Clone Cells; Down-Regulation; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Lymphocyte Activation; Muromonab-CD3; T-Lymphocyte Subsets