- Abstract:
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BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality. METHODS AND FINDINGS: Nineteen unpublishe...
Expand abstract - Publication status:
- Published
- Files:
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(pdf, 590.0kb)
-
- Publisher copy:
- 10.1371/journal.pmed.1001177
-
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- Journal:
- PLoS medicine
- Volume:
- 9
- Issue:
- 2
- Pages:
- e1001177
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
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1549-1676
- ISSN:
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1549-1277
- URN:
-
uuid:c769a660-5977-497a-bcba-a6c29a05f7ca
- Source identifiers:
-
312762
- Local pid:
- pubs:312762
- Copyright date:
- 2012
Journal article
Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.
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