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Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.

Abstract:

BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality. METHODS AND FINDINGS: Nineteen unpublishe...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pmed.1001177

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Verhoef, P More by this author
Dötsch-Klerk, M More by this author
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Journal:
PLoS medicine
Volume:
9
Issue:
2
Pages:
e1001177
Publication date:
2012-02-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:c769a660-5977-497a-bcba-a6c29a05f7ca
Source identifiers:
312762
Local pid:
pubs:312762

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