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Journal article

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.

Abstract:

BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality. METHODS AND FINDINGS: Nineteen unpublishe...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pmed.1001177

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Journal:
PLoS medicine
Volume:
9
Issue:
2
Pages:
e1001177
Publication date:
2012-02-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Source identifiers:
312762
Language:
English
Keywords:
Pubs id:
pubs:312762
UUID:
uuid:c769a660-5977-497a-bcba-a6c29a05f7ca
Local pid:
pubs:312762
Deposit date:
2012-12-19

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