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PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

Abstract:

mRNA modifications play important roles in regulating gene expression. One of the most abundant mRNA modifications is N6,2-O-dimethyladenosine (m6Am). Here, we demonstrate that m6Am is an evolutionarily conserved mRNA modification mediated by the Phosphorylated CTD Interacting Factor 1 (PCIF1), which catalyzes m6A methylation on 2-O-methylated adenine located at the 5′ ends of mRNAs. Furthermore, PCIF1 catalyzes only 5′ m6Am methylation of capped mRNAs but not internal m6A methylation in vitr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2019.05.030

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Publisher:
Elsevier
Journal:
Molecular Cell More from this journal
Volume:
75
Issue:
3
Pages:
620-630.e9
Publication date:
2019-07-03
Acceptance date:
2019-05-21
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Language:
English
Keywords:
Pubs id:
1124074
Local pid:
pubs:1124074
Deposit date:
2020-08-10

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