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Genome-wide DNaseI hypersensitive sites profiles in laboratory mouse strains by DNase-seq

Abstract:

Variation at regulatory elements, identified through hypersensitivity to digestion by Deoxyribonuclease I (DNase I), is believed to contribute to variation in complex traits, but the extent and consequences of this variation are poorly characterized. To investigate the relationship between sequence variation, and the functional consequences of variation in chromatin accessibility, genome-wide DNase I hypersensitive sites (DHS) of terminally differentiated erythroblasts were studied in eigh...

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Institution:
University of Oxford
Research group:
Wellcome Trust Centre for Human Genetics
Oxford college:
Christ Church
Department:
Medical Sciences Division

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:c76109fc-93b5-4e0b-b7df-0277cbf527a9
Local pid:
ora:7384

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