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Tools and talk: An evolutionary perspective on the functional deficits associated with amyotrophic lateral sclerosis

Abstract:

We propose that amyotrophic lateral sclerosis (ALS), and frontotemporal dementia may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations. We discuss how hand-arm function, locomotion, brainstem function (involving vocalization/speech, swallowing and breathing), and cognitive impairment share complex, interdependent evolutionary adaptations that can be traced back several million years. Fine movements of the hand facilitated tool-maki...

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Publisher copy:
10.1002/mus.24132

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Muscle and Nerve
Volume:
49
Issue:
4
Pages:
469-477
Publication date:
2014-04-05
DOI:
EISSN:
1097-4598
ISSN:
0148-639X
URN:
uuid:c75e849f-17a4-4c14-bd5c-4fb8eefff7cb
Source identifiers:
472345
Local pid:
pubs:472345

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