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Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.

Abstract:

The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling. The dual-substrate enzyme PDE10A is the most highly expressed PDE in striatal medium-sized spiny neurons (MSNs) with low micromolar affinity for both cyclic nucleotides. Previously, we have shown that systemic and local administration of the selective PDE10A inhibitor TP-10 potently increased the responsiveness of MSNs to cortical stimul...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1523/jneurosci.1238-14.2015

Authors


Padovan-Neto, FE More by this author
Chakroborty, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Pfizer Inc. More from this funder
United States Public Health More from this funder
Publisher:
Society for Neuroscience Publisher's website
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience Journal website
Volume:
35
Issue:
14
Pages:
5781-5791
Publication date:
2015-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:c74fb6bd-a9ea-4e0f-be00-11f008ad713a
Source identifiers:
518460
Local pid:
pubs:518460

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