Journal article
Transcriptionally Active Syncytial Aggregates in the Maternal Circulation May Contribute to Circulating Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia
- Abstract:
-
The cardinal manifestations of the pregnancy-specific disorder preeclampsia, new-onset hypertension, and proteinuria that resolve with placental delivery have been linked to an extracellular protein made by the placenta, soluble fms-like tyrosine kinase 1 (sFlt1), that injures the maternal vasculature. However, the mechanisms by which sFlt1, which is heavily matrix bound, gain access to the systemic circulation remain unclear. Here we report that the preeclamp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1161/hypertensionaha.111.182170
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Authors
Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Hypertension Journal website
- Volume:
- 59
- Issue:
- 2
- Pages:
- 256-264
- Publication date:
- 2012-01-03
- Acceptance date:
- 2011-12-05
- DOI:
- EISSN:
-
1524-4563
- ISSN:
-
0194-911X
- Source identifiers:
-
813665
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:813665
- UUID:
-
uuid:c74d10dd-5a4e-42fe-92e8-b4734b8ca401
- Local pid:
- pubs:813665
- Deposit date:
- 2019-06-23
Terms of use
- Copyright holder:
- American Heart Association
- Copyright date:
- 2012
- Notes:
- Copyright © 2012 American Heart Association, Inc.
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