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Transcriptionally Active Syncytial Aggregates in the Maternal Circulation May Contribute to Circulating Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia

Abstract:

The cardinal manifestations of the pregnancy-specific disorder preeclampsia, new-onset hypertension, and proteinuria that resolve with placental delivery have been linked to an extracellular protein made by the placenta, soluble fms-like tyrosine kinase 1 (sFlt1), that injures the maternal vasculature. However, the mechanisms by which sFlt1, which is heavily matrix bound, gain access to the systemic circulation remain unclear. Here we report that the preeclamp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
59
Issue:
2
Pages:
256-264
Publication date:
2012-01-03
Acceptance date:
2011-12-05
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Source identifiers:
813665
Language:
English
Keywords:
Pubs id:
pubs:813665
UUID:
uuid:c74d10dd-5a4e-42fe-92e8-b4734b8ca401
Local pid:
pubs:813665
Deposit date:
2019-06-23

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