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Thesis

Identification and characterisation of a lithium mimetic: enzymatic, cellular and animal investigations

Abstract:

It has been six decades since the discovery of lithium for the treatment of bipolar disorder. There is, as yet, no conclusive evidence as to how lithium produces this therapeutic effect, since it is known to interact with multiple cellular targets. One of the most credible targets is the enzyme, inositol monophosphatase (IMPase), which plays a crucial role in cell signalling. My aim was to find a novel IMPase inhibitor and evaluate it as a possible lithium-like mood stabiliser by using enz...

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Institution:
University of Oxford
Oxford college:
St Peter's College
Department:
Medical Sciences Division - Pharmacology
Role:
Author

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Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral

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