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Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis.

Abstract:

Cysteine cathepsins and matrix metalloproteases are considered to play important roles in the development of arthritic diseases. Their accumulation in synovial fluid of primarily rheumatoid arthritis patients is also well documented. However, a detailed comparison between the protease levels and activities between rheumatoid arthritis samples and osteoarthritis samples has never been made. Here, we report that both cysteine cathepsins B and S and matrix metalloproteases-1, -3 and -13 are dete...

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Publication status:
Published

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Publisher copy:
10.1515/bc.2010.035

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Biological chemistry
Volume:
391
Issue:
5
Pages:
571-579
Publication date:
2010-05-01
DOI:
EISSN:
1437-4315
ISSN:
1431-6730
Source identifiers:
227396

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