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Thesis

Metabolic maturation of induced pluripotent stem cells derived cardiomyocytes

Abstract:

Cardiac metabolism and function are inherently linked, as substrate metabolism generates the energy needed for the heart to beat. With the development of protocols to differentiate human induced pluripotent stem cells (iPSCs) into beating cardiomyocytes (CMs), cardiac cells can now be studied in vitro. This promises valuable insights into the biology of human CMs, however it is hindered by the fact that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) hav...

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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