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DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.

Abstract:

TAp63α, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. Remarkably, already undamaged oocytes express high levels of the protein, suggesting that TAp63α's activity is under tight control of an inhibitory mechanism. Biochemical studies have proposed that inhibition requires the C-terminal transactivation inhibitory domain. However, the structural mechanism of TAp63α inhibition remains unknown. Here, we show that TAp63α is kept in an inactive dimeric s...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2011.01.013

Authors


Deutsch, GB More by this author
Zielonka, EM More by this author
Coutandin, D More by this author
Schäfer, B More by this author
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Journal:
Cell
Volume:
144
Issue:
4
Pages:
566-576
Publication date:
2011-02-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:c739dc27-6d27-45fb-a04c-26a7c0b2cd82
Source identifiers:
120572
Local pid:
pubs:120572

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