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Journal article

Endothelial cell metabolism and implications for cancer therapy.

Abstract:

Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. The primarily glycolytic metabolism of tumour cells contributes to this, with increased glucose consumption and increased lactate secretion. Endothelial cells are particularly challenged when recruited towards the tumour metabolic environment. They are required to proliferate and form functional networks in order to establish continuous blood flow. Considering that deregulated metabo...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.2012.398
Journal:
British journal of cancer More from this journal
Volume:
107
Issue:
8
Pages:
1207-1212
Publication date:
2012-10-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
pubs:354028
UUID:
uuid:c73402d7-c78b-42f6-a85e-c5ff856b8545
Local pid:
pubs:354028
Source identifiers:
354028
Deposit date:
2013-11-16

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