Endothelial cell metabolism and implications for cancer therapy.

Journal article

Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. The primarily glycolytic metabolism of tumour cells contributes to this, with increased glucose consumption and increased lactate secretion. Endothelial cells are particularly challenged when recruited towards the tumour metabolic environment. They are required to proliferate and form functional networks in order to establish continuous blood flow. Considering that deregulated metabo...

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Authors: Harjes, U; Bensaad, K; Harris, A

• Publication status: Published
• Journal: British journal of cancer
• Volume: 107
• Issue: 8
• Pages: 1207-1212
• Publication date: 2012-10-01
• DOI: 10.1038/bjc.2012.398
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Lactic Acid; Neoplasms; Neovascularization, Pathologic; Glucose; Endothelial Cells; Humans; Glycolysis