Thesis
Structural and biophysical characterisation of the extra-cellular domains from the mammalian peptide transporters, PepT1 and PepT2
- Abstract:
-
PepT1 and PepT2 are integral membrane proteins which couple the uptake of di- and tri-peptides to the proton electro-chemical gradient. PepT1 is predominantly expressed in the small intestine and is the main route through which dietary protein is absorbed. PepT2 shares 46% sequence identity with PepT1 and is expressed in the kidneys, lung and central nervous system. Many commonly prescribed drugs, such as penicillin are peptide mimetics, and PepT1 and PepT2 play a direct role in their tran...
Expand abstract
Actions
Funding
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:c72b299c-8f45-454a-9bf9-8ce05620ad85
- Local pid:
- ora:12390
- Deposit date:
- 2016-02-10
Terms of use
- Copyright holder:
- John Beale
- Copyright date:
- 2015
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record