Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

Journal article

CD2 is a T lymphocyte glycoprotein that functions in adhesion of T lymphocytes and also as a putative receptor for activation signals. Functional data suggest that LFA-3, a widely distributed cell surface glycoprotein, may be the biological ligand of CD2. We have purified LFA-3 from human erythrocytes and characterized the purified protein functionally. LFA-3 bound specifically to CD2+ cells, and this binding was inhibited by CD2 mAb. Conversely, purified LFA-3 inhibited binding of CD2 mAb to...

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Authors: Dustin, M; Sanders, M; Shaw, S; Springer, T

• Journal: Journal of experimental medicine
• Volume: 165
• Issue: 3
• Pages: 677-692
• Publication date: 1987-03-01
• DOI: 10.1084/jem.165.3.677
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Antigens, Surface; Humans; Mice; Leukemia, Hairy Cell; Antigens, Differentiation, T-Lymphocyte; Spleen; Cell Adhesion; Sheep; Cell Membrane; Erythrocytes; T-Lymphocytes; B-Lymphocytes; Animals; Liposomes; Lymphocyte Function-Associated Antigen-1