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Comparative effects of cyclo-oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance.

Abstract:

1. This study examined the effects of the COX inhibitors, ketorolac and ibuprofen, and the NOS inhibitor L-NAME for their potential to both inhibit the development and reverse tolerance to the antinociceptive action of morphine. 2. Repeated administration of intrathecal morphine (15 micrograms), once daily, resulted in a progressive decline of antinociceptive effect and an increase in the ED50 value in the tailflick and paw pressure tests. Co-administration of ketorolac (30 and 45 micrograms)...

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Publisher copy:
10.1038/sj.bjp.0702587

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
British journal of pharmacology
Volume:
127
Issue:
3
Pages:
631-644
Publication date:
1999-06-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:c727676f-bc6d-49e4-aab8-389f2739e93d
Source identifiers:
323568
Local pid:
pubs:323568

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