The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments.

Journal article

Due to a combination of their promising anticancer properties, limited supply from the marine sponge source and their unprecedented molecular architecture, spirastrellolides represent attractive and challenging synthetic targets. A modular strategy for the synthesis of spirastrellolide A methyl ester, which allowed for the initial stereochemical uncertainties in the assigned structure was adopted, based on the envisaged sequential coupling of a series of suitably functionalised fragments; in ...

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Authors: Paterson, I; Anderson, E; Dalby, S; Lim, J; Maltas, P

• Publication status: Published
• Journal: Organic and biomolecular chemistry
• Volume: 10
• Issue: 30
• Pages: 5861-5872
• Publication date: 2012-08-01
• DOI: 10.1039/c2ob25100k
• EISSN: 1477-0539
• ISSN: 1477-0520
• Language: English
• Keywords: Vinyl Compounds; Spiro Compounds; Chemistry Techniques, Synthetic; Tin Compounds; Alkynes; Macrolides; Kinetics; Stereoisomerism; Substrate Specificity