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The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments.

Abstract:

Due to a combination of their promising anticancer properties, limited supply from the marine sponge source and their unprecedented molecular architecture, spirastrellolides represent attractive and challenging synthetic targets. A modular strategy for the synthesis of spirastrellolide A methyl ester, which allowed for the initial stereochemical uncertainties in the assigned structure was adopted, based on the envisaged sequential coupling of a series of suitably functionalised fragments; in ...

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Publication status:
Published

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Publisher copy:
10.1039/c2ob25100k

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Organic and biomolecular chemistry
Volume:
10
Issue:
30
Pages:
5861-5872
Publication date:
2012-08-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
URN:
uuid:c715d56a-6418-425d-9551-7d171ce305fb
Source identifiers:
325177
Local pid:
pubs:325177

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