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Cytotoxic T lymphocytes specific for murine type II collagen do not trigger arthritis in B10 mice.

Abstract:

To investigate the role of cytotoxic T lymphocytes (CTL) in arthritis, we set out to induce CTL specific for murine type II collagen (mCII) in a mouse model. The primary protein sequence of the murine pro-alpha 1(II) was screened for fragments bearing H-2 Db or Kb binding motifs. Six fragments were identified and the corresponding peptides synthesized. One of these peptides, peptide P201 (amino acid 199-208 in the C-propeptide of the murine pro-alpha 1(II), was found to be a strong binder to ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Clinical and experimental immunology
Volume:
103
Issue:
1
Pages:
89-93
Publication date:
1996-01-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:c712da8d-09db-431e-9a44-98ce79e010fc
Source identifiers:
45113
Local pid:
pubs:45113

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