Cytotoxic T lymphocytes specific for murine type II collagen do not trigger arthritis in B10 mice.
To investigate the role of cytotoxic T lymphocytes (CTL) in arthritis, we set out to induce CTL specific for murine type II collagen (mCII) in a mouse model. The primary protein sequence of the murine pro-alpha 1(II) was screened for fragments bearing H-2 Db or Kb binding motifs. Six fragments were identified and the corresponding peptides synthesized. One of these peptides, peptide P201 (amino acid 199-208 in the C-propeptide of the murine pro-alpha 1(II), was found to be a strong binder to ...Expand abstract
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