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Journal article

Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.

Abstract:

The properties of mutant contractile proteins that cause hypertrophic cardiomyopathy (HCM) have been investigated in expression studies and in mouse models. There is growing evidence that the precise isoforms of both the mutated protein and its interacting partners can qualitatively influence the effects of the mutation. We therefore investigated the functional effects of two HCM mutations in alpha -tropomyosin, Asp175Asn and Glu180Gly, in the in vitro motility assay using recombinant human a...

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Publication status:
Published

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Publisher copy:
10.1006/jmcc.2000.1182

Authors


Redwood, C More by this author
Esposito, G More by this author
Purcell, I More by this author
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Journal:
Journal of molecular and cellular cardiology
Volume:
32
Issue:
8
Pages:
1489-1498
Publication date:
2000-08-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:c70d933d-5a78-40f1-8301-44eab27bfc70
Source identifiers:
104318
Local pid:
pubs:104318

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