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The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extra-prostatic disease.

Abstract:

Prostate-specific antigen (PSA or hK3) is a glandular kallikrein with abundant expression in the prostate that is widely used to detect and monitor prostate cancer (PCa), although the serum level is frequently elevated also in benign and inflammatory prostatic diseases. PSA testing is useful for early detection of localized PCa and for the detection of disease recurrence after treatment. However, PSA has failed to accurately estimate cancer volume and preoperative staging. There is no PSA lev...

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Publisher copy:
10.1080/20014091084236

Authors


Diamandis, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Journal:
Critical reviews in clinical laboratory sciences
Volume:
38
Issue:
5
Pages:
357-399
Publication date:
2001-10-05
DOI:
EISSN:
1549-781X
ISSN:
1040-8363
URN:
uuid:c70abddd-f7d3-4946-842d-0e7e9dc2b5ce
Source identifiers:
366022
Local pid:
pubs:366022

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