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Cardiac phenotyping in ex vivo murine embryos using microMRI.

Abstract:

Microscopic MRI (microMRI) is an emerging technique for high-throughput phenotyping of transgenic mouse embryos, and is capable of visualising abnormalities in cardiac development. To identify cardiac defects in embryos, we have optimised embryo preparation and MR acquisition parameters to maximise image quality and assess the phenotypic changes in chromodomain helicase DNA-binding protein 7 (Chd7) transgenic mice. microMRI methods rely on tissue penetration with a gadolinium chelate contrast...

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Publication status:
Published

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Publisher copy:
10.1002/nbm.1400

Authors


Cleary, JO More by this author
Thomas, DL More by this author
Scambler, PJ More by this author
Kyriakopoulou, V More by this author
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Journal:
NMR in biomedicine
Volume:
22
Issue:
8
Pages:
857-866
Publication date:
2009-10-05
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
URN:
uuid:c705113c-1a04-4c63-b5a6-47b337f7d755
Source identifiers:
105889
Local pid:
pubs:105889

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