Journal article
Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory
- Abstract:
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The magnitude of negative selection on alleles involved in age-specific mortality decreases with age. This is the foundation of the evolutionary theory of senescence. Because of this decrease in negative selection with age, and because of the absence of reproduction after menopause, alleles involved in women's late-onset diseases are generally considered evolutionarily neutral. Recently, genetic and epidemiological data on alleles involved in late onset-diseases have become available. It is t...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Version of record, pdf, 236.0KB)
-
- Publisher copy:
- 10.1371/journal.pone.0001206
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 2
- Issue:
- 11
- Pages:
- e1206
- Publication date:
- 2007-11-21
- Acceptance date:
- 2007-10-29
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:c6fd3195-ab61-4514-b5c7-f130f8641be4
- Local pid:
- pubs:314556
- Source identifiers:
-
314556
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Pavard and Metcalf
- Copyright date:
- 2007
- Notes:
- © 2007 Pavard, Metcalf. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in
- Licence:
- CC Attribution (CC BY)
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