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Journal article

Irradiated wild-type and Spa mutant Staphylococcus aureus induce anti-S. aureus immune responses in mice which do not protect against subsequent intravenous challenge.

Abstract:

Staphylococcus aureus remains an important human and animal pathogen. Its pathogenicity is determined in part by expression of the Spa-immune subversion protein, neutralising the activity of which provides partial protection in murine models, as does experimental infection with live S. aureus with Spa gene deletions followed by antibiotic-mediated cure in mice. Together, these data raise the question of whether Spa mutant S. aureus might represent a viable vaccine. Here, we find that gamma-ir...

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Publication status:
Published

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Publisher copy:
10.1111/2049-632x.12042

Authors


van Diemen, PM More by this author
Yamaguchi, Y More by this author
Paterson, GK More by this author
Rollier, CS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
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Publisher:
Blackwell Publishing Ltd
Journal:
Pathogens and disease
Volume:
68
Issue:
1
Pages:
20-26
Publication date:
2013-06-05
DOI:
EISSN:
2049-632X
ISSN:
2049-632X
URN:
uuid:c6f969cb-fcc8-4acd-8cfe-e90ec32327a1
Source identifiers:
401252
Local pid:
pubs:401252

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