Journal article icon

Journal article

Irradiated wild-type and Spa mutant Staphylococcus aureus induce anti-S. aureus immune responses in mice which do not protect against subsequent intravenous challenge.

Abstract:

Staphylococcus aureus remains an important human and animal pathogen. Its pathogenicity is determined in part by expression of the Spa-immune subversion protein, neutralising the activity of which provides partial protection in murine models, as does experimental infection with live S. aureus with Spa gene deletions followed by antibiotic-mediated cure in mice. Together, these data raise the question of whether Spa mutant S. aureus might represent a viable vaccine. Here, we find that gamma-ir...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1111/2049-632x.12042

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Expand authors...
Publisher:
Blackwell Publishing Ltd
Journal:
Pathogens and disease
Volume:
68
Issue:
1
Pages:
20-26
Publication date:
2013-06-01
DOI:
EISSN:
2049-632X
ISSN:
2049-632X
Source identifiers:
401252
Language:
English
Keywords:
Pubs id:
pubs:401252
UUID:
uuid:c6f969cb-fcc8-4acd-8cfe-e90ec32327a1
Local pid:
pubs:401252
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP