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GRADE guidelines: 9. Rating up the quality of evidence.

Abstract:

The most common reason for rating up the quality of evidence is a large effect. GRADE suggests considering rating up quality of evidence one level when methodologically rigorous observational studies show at least a two-fold reduction or increase in risk, and rating up two levels for at least a five-fold reduction or increase in risk. Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all plausi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Role:
Author
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Journal:
Journal of clinical epidemiology
Volume:
64
Issue:
12
Pages:
1311-1316
Publication date:
2011-12-05
DOI:
EISSN:
1878-5921
ISSN:
0895-4356
URN:
uuid:c6e9501f-a1a5-485b-b80b-8fe227541df6
Source identifiers:
215685
Local pid:
pubs:215685

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