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CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.

Abstract:

The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer therapy for tumors with high levels of hypoxia-induced replication stress. However, as inhibition of Chk1 affects normal replication and induces DNA damage, these agents also have the potential to induce genomic instability and contribute to tumo...

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Publication status:
Published

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Publisher copy:
10.1021/cb4001537

Authors


Cazares-Körner, C More by this author
Swallow, ID More by this author
Grayer, SC More by this author
O'Connor, LJ More by this author
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Journal:
ACS chemical biology
Volume:
8
Issue:
7
Pages:
1451-1459
Publication date:
2013-07-05
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
URN:
uuid:c6e91094-c83a-4466-b440-420273fe4aab
Source identifiers:
398528
Local pid:
pubs:398528

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