- Abstract:
-
The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer therapy for tumors with high levels of hypoxia-induced replication stress. However, as inhibition of Chk1 affects normal replication and induces DNA damage, these agents also have the potential to induce genomic instability and contribute to tumo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/cb4001537
-
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- Journal:
- ACS chemical biology
- Volume:
- 8
- Issue:
- 7
- Pages:
- 1451-1459
- Publication date:
- 2013-07-05
- DOI:
- EISSN:
-
1554-8937
- ISSN:
-
1554-8929
- URN:
-
uuid:c6e91094-c83a-4466-b440-420273fe4aab
- Source identifiers:
-
398528
- Local pid:
- pubs:398528
- Copyright date:
- 2013
Journal article
CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.
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