Journal article
CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.
- Abstract:
-
The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer therapy for tumors with high levels of hypoxia-induced replication stress. However, as inhibition of Chk1 affects normal replication and induces DNA damage, these agents also have the potential to induce genomic instability and contribute to tumo...
Expand abstract
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- ACS chemical biology
- Volume:
- 8
- Issue:
- 7
- Pages:
- 1451-1459
- Publication date:
- 2013-07-01
- DOI:
- EISSN:
-
1554-8937
- ISSN:
-
1554-8929
- Source identifiers:
-
398528
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:398528
- UUID:
-
uuid:c6e91094-c83a-4466-b440-420273fe4aab
- Local pid:
- pubs:398528
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2013
If you are the owner of this record, you can report an update to it here: Report update to this record