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Journal article

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

Abstract:

Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which encodes a vital negative regulatory molecule of the immune system--as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes. In humans, disease susceptibility was ...

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Publisher copy:
10.1038/nature01621

Authors


Howson, JM More by this author
Esposito, L More by this author
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Journal:
Nature
Volume:
423
Issue:
6939
Pages:
506-511
Publication date:
2003-05-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:c6e58d6d-7c43-4d5d-a8c2-1ca63038fa59
Source identifiers:
176270
Local pid:
pubs:176270

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