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Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.

Abstract:

Infection with influenza A virus (IAV) presents a substantial threat to public health worldwide, with young, elderly, and immunodeficient individuals being particularly susceptible. Inflammatory responses play an important role in the fatal outcome of IAV infection, but the mechanism remains unclear. We demonstrate here that the absence of invariant NKT (iNKT) cells in mice during IAV infection resulted in the expansion of myeloid-derived suppressor cells (MDSCs), which suppressed IAV-specifi...

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Publisher copy:
10.1172/jci36264

Authors


De Santo, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
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Journal:
The Journal of clinical investigation
Volume:
118
Issue:
12
Pages:
4036-4048
Publication date:
2008-12-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:c6e230f1-7e38-4796-897a-1776ac38e661
Source identifiers:
34492
Local pid:
pubs:34492

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