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How B cell receptor repertoire sequencing can be enriched with structural antibody data

Abstract:

Next-generation sequencing of immunoglobulin gene repertoires (Ig-seq) allows the investigation of large-scale antibody dynamics at a sequence level. However, structural information, a crucial descriptor of antibody binding capability is not collected in Ig-seq protocols. Developing systematic relationships between the antibody sequence information gathered from Ig-seq and low-throughput techniques such as X-ray crystallography could radically improve our understanding of antibodies. The mapp...

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Publication status:
Accepted
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.3389/fimmu.2017.01753

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Galson, JD More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Oxford college:
Kellogg College
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UCB Pharma Ltd More from this funder
NIHR Oxford Biomedical Research Centre More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Pages:
Article: 1753
Publication date:
2017-12-05
Acceptance date:
2017-11-27
DOI:
EISSN:
1664-3224
Pubs id:
pubs:807178
URN:
uri:c6e0b063-ac10-48ce-8574-cc4522f5d807
UUID:
uuid:c6e0b063-ac10-48ce-8574-cc4522f5d807
Local pid:
pubs:807178

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