- Abstract:
-
Validated methods for the determination of CA1, the active agent derived from the prodrug CA1P, in human plasma and urine, and of CA1P and three glucuronides CA1G1, CA1G2 and CA1DG in human urine were developed using LC-MS. Plasma CA1 was extracted using solid phase extraction and validated over the range 5-1000 nM. Urine samples were analysed without extraction, and the assays validated over the range 50-2000 nM (CA1P), 25-2000 nM (CA1), 50-40,000 nM (CA1G1 and CA1G2) and 25-4000 nM (CA1DG)....
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jchromb.2012.03.040
-
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- Journal:
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Volume:
- 898
- Pages:
- 1-6
- Publication date:
- 2012-06-05
- DOI:
- EISSN:
-
1873-376X
- ISSN:
-
1570-0232
- URN:
-
uuid:c6d5e81a-3178-469f-89b5-69d722b541a3
- Source identifiers:
-
324014
- Local pid:
- pubs:324014
- Copyright date:
- 2012
Journal article
Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection.
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