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Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection.

Abstract:

Validated methods for the determination of CA1, the active agent derived from the prodrug CA1P, in human plasma and urine, and of CA1P and three glucuronides CA1G1, CA1G2 and CA1DG in human urine were developed using LC-MS. Plasma CA1 was extracted using solid phase extraction and validated over the range 5-1000 nM. Urine samples were analysed without extraction, and the assays validated over the range 50-2000 nM (CA1P), 25-2000 nM (CA1), 50-40,000 nM (CA1G1 and CA1G2) and 25-4000 nM (CA1DG)....

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Publication status:
Published

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Journal:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Volume:
898
Pages:
1-6
Publication date:
2012-06-05
DOI:
EISSN:
1873-376X
ISSN:
1570-0232
URN:
uuid:c6d5e81a-3178-469f-89b5-69d722b541a3
Source identifiers:
324014
Local pid:
pubs:324014

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