Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately 5-10% of PD patients have a familial form of Parkinsonism, including mutations in α-synuclein. To better understand the cell-type specific role of α-synuclein on DA neurotransmission, and the effects of the disease-associated A30P mutation, we generated and ...Expand abstract
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© 2013 The Authors. Published by Elsevier Inc. Open access under a Creative Commons CC BY license. Open Access funded by Wellcome Trust.
articletitle: Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
journaltitle: Neurobiology of Disease
copyright: Copyright © 2013 Elsevier Inc.