Journal article
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.
- Abstract:
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Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately 5-10% of PD patients have a familial form of Parkinsonism, including mutations in α-synuclein. To better understand the cell-type specific role of α-synuclein on DA neurotransmission, and the effects of the disease-associated A30P mutation, we generated and ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 2.3MB)
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- Publisher copy:
- 10.1016/j.nbd.2013.10.005
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Authors
Funding
Parkinson's UK
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Medical Research Council
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neurobiology of disease Journal website
- Volume:
- 62
- Pages:
- 193-207
- Chapter number:
- C
- Publication date:
- 2014-02-05
- DOI:
- EISSN:
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1095-953X
- ISSN:
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0969-9961
- URN:
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uuid:c6c1f55b-1a66-493e-a50f-ad954275b60a
- Source identifiers:
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433421
- Local pid:
- pubs:433421
Item Description
Terms of use
- Copyright holder:
- The Authors
- Copyright date:
- 2014
- Notes:
-
© 2013 The Authors. Published by Elsevier Inc. Open access under a Creative Commons CC BY license. Open Access funded by Wellcome Trust.
publisher: Elsevier
articletitle: Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
journaltitle: Neurobiology of Disease
articlelink: http://dx.doi.org/10.1016/j.nbd.2013.10.005
content_type: article
copyright: Copyright © 2013 Elsevier Inc.
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