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Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.

Abstract:

Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately 5-10% of PD patients have a familial form of Parkinsonism, including mutations in α-synuclein. To better understand the cell-type specific role of α-synuclein on DA neurotransmission, and the effects of the disease-associated A30P mutation, we generated and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.nbd.2013.10.005

Authors


Taylor, TN More by this author
Potgieter, D More by this author
Senior, SL More by this author
Janezic, S More by this author
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Funding agency for:
Anwar, S
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Funding agency for:
Wade-Martins, R
Parkinson's UK More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of disease Journal website
Volume:
62
Pages:
193-207
Publication date:
2014-02-05
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
URN:
uuid:c6c1f55b-1a66-493e-a50f-ad954275b60a
Source identifiers:
433421
Local pid:
pubs:433421

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