- Abstract:
-
Paediatric B-precursor ALL is a highly curable disease, however, treatment resistance in some patients and the long-term toxic effects of current therapies pose the need for more targeted therapeutic approaches. We addressed the cytotoxic effect of JQ1, a highly selective inhibitor against the transcriptional regulators, bromodomain and extra-terminal (BET) family of proteins, in paediatric ALL. We showed a potent in vitro cytotoxic response of a panel of primary ALL to JQ1, independent of th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/bcj.2013.24
-
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- Journal:
- Blood cancer journal
- Volume:
- 3
- Issue:
- 7
- Pages:
- e126
- Publication date:
- 2013-01-01
- DOI:
- EISSN:
-
2044-5385
- ISSN:
-
2044-5385
- URN:
-
uuid:c6c07d62-89e3-4c35-b9c5-a3a472d7f44e
- Source identifiers:
-
416744
- Local pid:
- pubs:416744
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.
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