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Journal article

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.

Abstract:

Paediatric B-precursor ALL is a highly curable disease, however, treatment resistance in some patients and the long-term toxic effects of current therapies pose the need for more targeted therapeutic approaches. We addressed the cytotoxic effect of JQ1, a highly selective inhibitor against the transcriptional regulators, bromodomain and extra-terminal (BET) family of proteins, in paediatric ALL. We showed a potent in vitro cytotoxic response of a panel of primary ALL to JQ1, independent of th...

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Publication status:
Published

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Publisher copy:
10.1038/bcj.2013.24

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Journal:
Blood cancer journal
Volume:
3
Issue:
7
Pages:
e126
Publication date:
2013-01-01
DOI:
EISSN:
2044-5385
ISSN:
2044-5385
URN:
uuid:c6c07d62-89e3-4c35-b9c5-a3a472d7f44e
Source identifiers:
416744
Local pid:
pubs:416744
Language:
English
Keywords:

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