Journal article
In vivo microbial coevolution favours host protection and plastic downregulation of immunity
- Abstract:
- Microbiota can protect their hosts from infection. The short timescales in which microbes can evolve presents the possibility that ‘protective microbes’ can take-over from the immune system of longer-lived hosts in the coevolutionary race against pathogens. Here, we found that coevolution between a protective bacterium (Enterococcus faecalis) and a virulent pathogen (Staphylococcus aureus) within an animal population (Caenorhabditis elegans) resulted in more disease suppression than when the protective bacterium adapted to uninfected hosts. At the same time, more protective E. faecalis populations became costlier to harbour and altered the expression of 134 host genes. Many of these genes appear to be related to the mechanism of protection, reactive oxygen species production. Crucially, more protective E. faecalis populations downregulated a key immune gene, sodh-1, known to be effective against S. aureus infection. These results suggest that a microbial line of defence is favoured by microbial coevolution and may cause hosts to plastically divest of their own immunity.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 554.9KB, Terms of use)
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- Publisher copy:
- 10.1093/molbev/msaa292
Authors
- Publisher:
- Oxford University Press
- Journal:
- Molecular Biology and Evolution More from this journal
- Volume:
- 38
- Issue:
- 4
- Pages:
- 1330–1338
- Publication date:
- 2020-11-12
- Acceptance date:
- 2020-11-02
- DOI:
- EISSN:
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1537-1719
- ISSN:
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0737-4038
- Language:
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English
- Keywords:
- Pubs id:
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1140660
- Local pid:
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pubs:1140660
- Deposit date:
-
2020-11-06
Terms of use
- Copyright holder:
- Ford and King.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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