Back to Search
Thesis icon

Thesis

Biophysical studies on enzymes related to antibiotics

Abstract:

The work described in this thesis concerns two research areas: (i) time resolved (tr) crystallography studies on two enzymes, oxacillinase 10 (OXA-10) and isopenicillin N synthase (IPNS); and (ii) the reactivity of formaldehyde towards amino acids. OXA-10 is a class D serine β-lactamase that confers bacterial resistance against clinically relevant β-lactam antibiotics. IPNS is a non-heme Fe dependent enzyme that catalyses the formation of isopenicillin N (IPN) from L-δ-(α-aminoadipoyl)-L-c...

Expand abstract

Actions

  • Cite

  • Print

Access Document

Files:

Authors

More by this author
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
St Peter's College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
Deposit date:
2020-09-28

Terms of use

Views and Downloads





If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP