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Journal article

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.

Abstract:

Inherited mutations in BRCA2 are associated with a predisposition to early-onset breast cancers. The underlying basis of tumorigenesis is thought to be linked to defects in DNA double-strand break repair by homologous recombination. Here we show that the carboxy-terminal region of BRCA2, which interacts directly with the essential recombination protein RAD51, contains a site (serine 3291; S3291) that is phosphorylated by cyclin-dependent kinases. Phosphorylation of S3291 is low in S phase whe...

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Publication status:
Published

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Publisher copy:
10.1038/nature03404

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Nature
Volume:
434
Issue:
7033
Pages:
598-604
Publication date:
2005-03-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:c6ab4cc4-4a67-461b-b987-5972bbc26508
Source identifiers:
55307
Local pid:
pubs:55307

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