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Journal article

The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles

Abstract:

Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a range of disorders, including bipolar disorder and Alzheimer's disease. To date, most inositol studies have focused on the molecular and cellular effects of inositol depletion without considering Ino1 levels. Here we employ a simple eukaryote, Dictyostelium discoideum, to demonstrate distinct effects of loss of Ino1 and inositol depletion. We show that loss of Ino1 results in an inosi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/MCB.00039-16

Authors


Le Roy, CI More by this author
Thomason, PA More by this author
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Doctor Hadwen Trust More from this funder
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Molecular and Cellular Biology Journal website
Volume:
36
Issue:
10
Pages:
1464-1479
Publication date:
2016-05-01
Acceptance date:
2016-03-03
DOI:
ISSN:
0270-7306 and 1098-5549
Pubs id:
pubs:609539
URN:
uri:c6a49884-dd35-4ef3-a8de-4a924e0a4c18
UUID:
uuid:c6a49884-dd35-4ef3-a8de-4a924e0a4c18
Local pid:
pubs:609539
Language:
English
Keywords:

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