- Abstract:
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Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a range of disorders, including bipolar disorder and Alzheimer's disease. To date, most inositol studies have focused on the molecular and cellular effects of inositol depletion without considering Ino1 levels. Here we employ a simple eukaryote, Dictyostelium discoideum, to demonstrate distinct effects of loss of Ino1 and inositol depletion. We show that loss of Ino1 results in an inosi...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.7mb)
-
- Publisher copy:
- 10.1128/MCB.00039-16
-
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- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Molecular and Cellular Biology Journal website
- Volume:
- 36
- Issue:
- 10
- Pages:
- 1464-1479
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-03-03
- DOI:
- ISSN:
-
0270-7306 and 1098-5549
- Pubs id:
-
pubs:609539
- URN:
-
uri:c6a49884-dd35-4ef3-a8de-4a924e0a4c18
- UUID:
-
uuid:c6a49884-dd35-4ef3-a8de-4a924e0a4c18
- Local pid:
- pubs:609539
- Language:
- English
- Keywords:
- Copyright holder:
- Anna Frej et al.
- Copyright date:
- 2016
- Notes:
-
This is an open-access article distributed under the
terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/).
Journal article
The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles
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Doctor Hadwen Trust
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National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
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