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Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins.

Abstract:

Endogenous oxidative stress is a likely cause of cardiac myocyte death in vivo. We examined the early (0-2 h) changes in the proteome of isolated cardiac myocytes from neonatal rats exposed to H2O2 (0.1 mM), focussing on proteins with apparent molecular masses of between 20 and 30 kDa. Proteins were separated by two-dimensional gel electrophoresis (2DGE), located by silver-staining and identified by mass spectrometry. Incorporation of [35S]methionine or 32Pi was also studied. For selected pro...

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Publication status:
Published

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Publisher copy:
10.1016/j.yjmcc.2005.10.004

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of molecular and cellular cardiology
Volume:
40
Issue:
1
Pages:
157-172
Publication date:
2006-01-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:c69e6d8b-4c7e-4705-b04f-55b0283feba2
Source identifiers:
230741
Local pid:
pubs:230741

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