Thesis
Analysis and prediction of selectivity in biological and chemical space
- Abstract:
-
Small molecules can be designed to interact with a specific protein or proteins, and, by extension, to modulate the biological pathways in which the respective protein is involved. Small molecules can thus influence a disease phenotype on a cellular, tissue, or organism level. However, some compounds, so-called ‘promiscuous’ compounds, modulate the phenotype by binding to a wide range of on- and off-targets. In the case of drugs, this binding to off-targets can be responsible for side effe...
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Authors
Contributors
+ Morris, G
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Supervisor
+ Deane, C
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Supervisor
+ Sach-Peltason, L
Institution:
F. Hoffmann-La Roche AG
Role:
Supervisor
+ Leddin, M
Institution:
F. Hoffmann-La Roche AG
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Deposit date:
- 2021-03-16
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Terms of use
- Copyright holder:
- Nierobisch, AF
- Copyright date:
- 2020
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