Warfarin thromboprophylaxis in cancer patients with central venous catheters (WARP): an open-label randomised trial.

Journal article

BACKGROUND: The role and dose of anticoagulants in thromboprophylaxis for patients with cancer receiving chemotherapy through central venous catheters (CVCs) is controversial. We therefore assessed whether warfarin reduces catheter-related thrombosis compared with no warfarin and whether the dose of warfarin determines the thromboprophylactic effect. METHODS: In 68 clinical centres in the UK, we randomly assigned 1590 patients aged at least 16 years with cancer who were receiving chemotherapy...

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Authors: Young, A; Billingham, L; Begum, G; Kerr, D; Hughes, A

• Journal: Lancet
• Volume: 373
• Issue: 9663
• Pages: 567-574
• Publication date: 2009-02-01
• DOI: 10.1016/s0140-6736(09)60205-1
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: WARP Collaborative Group, UK; Male; Aged; Female; Neoplasms; Anticoagulants; International Normalized Ratio; Warfarin; Middle Aged; Hemorrhage; Meta-Analysis as Topic; Catheterization, Central Venous; Antineoplastic Agents; Humans; Venous Thrombosis