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Journal article

Maintenance of CD4 T cell fitness through regulation of Foxo1

Abstract:

Foxo transcription factors play an essential role in regulating specialized lymphocyte functions, and in maintenance of T cell quiescence. Here, we used a system where Foxo1 transcription factor activity, normally terminated upon cell activation, cannot be silenced and show that enforcing Foxo1 activity disrupts CD4 conventional and regulatory T cell homeostasis. Despite limiting cell metabolism, continued Foxo1 activity is associated with increased activation of the kinase Akt and a cell int...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41590-018-0157-4

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Volume:
19
Pages:
838–848
Publication date:
2018-07-09
Acceptance date:
2018-05-07
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:853887
URN:
uri:c6808a2c-7fa5-4dd2-9780-63d37b223306
UUID:
uuid:c6808a2c-7fa5-4dd2-9780-63d37b223306
Local pid:
pubs:853887

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