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Integrated selective enrichment target--a microtechnology platform for matrix-assisted laser desorption/ionization-mass spectrometry applied on protein biomarkers in prostate diseases.

Abstract:

The performance of a miniaturized sample processing platform for matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), manufactured by silicon microfabrication, called integrated selective enrichment target (ISET) technology was evaluated in a biological context. The ISET serves as both sample treatment device and MALDI-MS target, and contains an array of 96 perforated nanovials, which each can be filled with 40 nL of reversed-phase beads. This methodology minimizes the nu...

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Publisher copy:
10.1002/elps.200406094

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Journal:
Electrophoresis
Volume:
25
Issue:
21-22
Pages:
3769-3777
Publication date:
2004-11-01
DOI:
EISSN:
1522-2683
ISSN:
0173-0835
Source identifiers:
365984

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