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Distinct microRNA alterations characterize high- and low-grade bladder cancer

Abstract:

Urothelial carcinoma of the bladder (UCC) is a common disease that arises by at least two different molecular pathways. The biology of UCC is incompletely understood, making the management of this disease difficult. Recent evidence implicates a regulatory role for microRNA in cancer. We hypothesized that altered microRNA expression contributes to UCC carcinogenesis. To test this hypothesis, we examined the expression of 322 microRNAs and their processing machinery in 78 normal and malignant u...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Sheffield
Department:
Institute for Cancer Studies
Role:
Author
More by this author
Institution:
University of Sheffield
Department:
Institute for Cancer Studies
Role:
Author
More by this author
Institution:
University of Sheffield
Department:
Institute for Cancer Studies
Role:
Author
More by this author
Institution:
University of Sheffield
Department:
Institute for Cancer Studies
Role:
Author
More by this author
Institution:
University of Sheffield
Department:
Institute for Cancer Studies
Role:
Author
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
69
Issue:
21
Pages:
8472-8481
Publication date:
2009-11-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Keywords:
Subjects:
UUID:
uuid:c6705ebb-cd5b-4a22-97ed-8136e168b75c
Local pid:
ora:5135
Deposit date:
2011-03-17

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