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Journal article

Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor.

Abstract:

Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine receptor (fAChR) as a specific cell surface target in rhabdomyosarcoma. Here, we engineered human T lymphocytes to express chimeric receptors composed of the antigen-binding domain...

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Publication status:
Published

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Authors


Gattenlöhner, S More by this author
Markfort, B More by this author
Pscherer, S More by this author
Landmeier, S More by this author
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Journal:
Cancer research
Volume:
66
Issue:
1
Pages:
24-28
Publication date:
2006-01-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:c66d53b5-e40e-459e-a9a9-13478c10bf02
Source identifiers:
242898
Local pid:
pubs:242898

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