- Abstract:
-
Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine receptor (fAChR) as a specific cell surface target in rhabdomyosarcoma. Here, we engineered human T lymphocytes to express chimeric receptors composed of the antigen-binding domain...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/0008-5472.can-05-0542
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- Journal:
- Cancer research
- Volume:
- 66
- Issue:
- 1
- Pages:
- 24-28
- Publication date:
- 2006-01-05
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- URN:
-
uuid:c66d53b5-e40e-459e-a9a9-13478c10bf02
- Source identifiers:
-
242898
- Local pid:
- pubs:242898
- Copyright date:
- 2006
Journal article
Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor.
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