GATA-2 regulates granulocyte-macrophage progenitor cell function.

Journal article

The zinc finger transcription factor GATA-2 has been implicated in the regulation of hematopoietic stem cells. Herein, we explored the role of GATA-2 as a candidate regulator of the hematopoietic progenitor cell compartment. We showed that bone marrow from GATA-2 heterozygote (GATA-2(+/-)) mice displayed attenuated granulocyte-macrophage progenitor function in colony-forming cell (CFC) and serial replating CFC assays. This defect was mapped to the Lin(-)CD117(+)Sca-1(-)CD34(+)CD16/32(high) gr...

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Authors: Rodrigues, N; Boyd, A; Fugazza, C; May, G; Guo, Y

• Publication status: Published
• Journal: Blood
• Volume: 112
• Issue: 13
• Pages: 4862-4873
• Publication date: 2008-12-01
• DOI: 10.1182/blood-2008-01-136564
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Protein Binding; GATA2 Transcription Factor; RNA Interference; Genotype; Mice, Mutant Strains; Granulocyte-Macrophage Progenitor Cells; Cell Line; Mice; Animals; Gene Expression Profiling