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A multiphase model for chemically- and mechanically- induced cell differentiation in a hollow fibre membrane bioreactor: minimising growth factor consumption

Abstract:

We present a simplified two-dimensional model of fluid flow, solute transport, and cell distribution in a hollow fibre membrane bioreactor. We consider two cell populations, one undifferentiated and one differentiated, with differentiation stimulated either by growth factor alone, or by both growth factor and fluid shear stress. Two experimental configurations are considered, a 3-layer model in which the cells are seeded in a scaffold throughout the extracapillary space (ECS), and a 4-layer m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1007/s10237-015-0717-6

Authors


Pearson, NC More by this author
Oliver, JM More by this author
Shipley, RJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Institute
Publisher:
Springer Verlag (Germany) Publisher's website
Journal:
Biomechanics and Modeling in Mechanobiology Journal website
Volume:
15
Issue:
3
Pages:
683-700
Publication date:
2015-08-15
Acceptance date:
2015-08-04
DOI:
EISSN:
1617-7940
ISSN:
1617-7959
URN:
uuid:c660109c-bce0-4704-be90-0220f0eb1038
Source identifiers:
539623
Local pid:
pubs:539623

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