Journal article
A multiphase model for chemically- and mechanically- induced cell differentiation in a hollow fibre membrane bioreactor: minimising growth factor consumption
- Abstract:
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We present a simplified two-dimensional model of fluid flow, solute transport, and cell distribution in a hollow fibre membrane bioreactor. We consider two cell populations, one undifferentiated and one differentiated, with differentiation stimulated either by growth factor alone, or by both growth factor and fluid shear stress. Two experimental configurations are considered, a 3-layer model in which the cells are seeded in a scaffold throughout the extracapillary space (ECS), and a 4-layer m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.4MB)
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- Publisher copy:
- 10.1007/s10237-015-0717-6
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Authors
Bibliographic Details
- Publisher:
- Springer Verlag Publisher's website
- Journal:
- Biomechanics and Modeling in Mechanobiology Journal website
- Volume:
- 15
- Issue:
- 3
- Pages:
- 683-700
- Publication date:
- 2015-08-15
- Acceptance date:
- 2015-08-04
- DOI:
- EISSN:
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1617-7940
- ISSN:
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1617-7959
- Source identifiers:
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539623
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:539623
- UUID:
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uuid:c660109c-bce0-4704-be90-0220f0eb1038
- Local pid:
- pubs:539623
- Deposit date:
- 2016-07-19
Terms of use
- Copyright holder:
- Springer-Verlag Berlin Heidelberg
- Copyright date:
- 2015
- Notes:
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This is the author accepted manuscript following peer review version of the article. The final version is
available online from Springer at: https://doi.org/10.1007/s10237-015-0717-6
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