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Journal article

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

Abstract:

Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases in TCR signaling impacted upon opposing TCR functions of immunity and tolerance. One Zap70 variant, murdock, moderately decreased TCR signaling and thymic selection without compr...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Immunity
Volume:
27
Issue:
6
Pages:
912-926
Publication date:
2007-12-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:c65e13b3-7588-421d-8381-21bd37c1d426
Source identifiers:
418828
Local pid:
pubs:418828

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