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Journal article

123I-labeled HIV-1 tat peptide radioimmunoconjugates are imported into the nucleus of human breast cancer cells and functionally interact in vitro and in vivo with the cyclin-dependent kinase inhibitor, p21(WAF-1/Cip-1).

Abstract:

PURPOSE: To evaluate the internalization and nuclear translocation of (123)I-tat-peptide radioimmunoconjugates in MDA-MB-468 breast cancer cells and their ability to interact with the cyclin-dependent kinase inhibitor, p21(WAF-1/Cip-1). METHODS: Peptides [GRKKRRQRRRPPQGYGC] harboring the nuclear-localizing sequence from HIV tat domain were conjugated to anti-p21(WAF-1/Cip-1) antibodies. Immunoreactivity was assessed by Western blot using lysate from MDA-MB-468 cells exposed to EGF to induce p...

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Publication status:
Published

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Publisher copy:
10.1007/s00259-006-0189-0

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
European journal of nuclear medicine and molecular imaging
Volume:
34
Issue:
3
Pages:
368-377
Publication date:
2007-03-05
DOI:
EISSN:
1619-7089
ISSN:
1619-7070
URN:
uuid:c65a7e9d-8104-45c9-8ad3-7c358f0848a8
Source identifiers:
131118
Local pid:
pubs:131118

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