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Influenza A virus challenge models in Cynomolgus macaques using the authentic inhaled aerosol and intra-nasal routes of infection

Abstract:

Non-human primates are the animals closest to humans for use in influenza A virus challenge studies, in terms of their phylogenetic relatedness, physiology and immune systems. Previous studies have shown that cynomolgus macaques (Macaca fascicularis) are permissive for infection with H1N1pdm influenza virus. These studies have typically used combined challenge routes, with the majority being intra-tracheal delivery, and high doses of virus (> 107 infectious units). This paper describes the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0157887

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Role:
Editor
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
6
Pages:
e0157887
Publication date:
2016-06-01
Acceptance date:
2016-06-06
DOI:
EISSN:
1932-6203
Source identifiers:
801740
Pubs id:
pubs:801740
UUID:
uuid:c653f90f-9442-4386-8bb2-158a2f65e20a
Local pid:
pubs:801740
Deposit date:
2017-12-20

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