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Interactions between the Nrf2 antioxidant response and mammalian iron homeostasis

Abstract:

Iron is an essential micronutrient as it contributes to the oxygen-carrying capacity of blood and is a cofactor for many enzymes. However, excess iron is toxic as it promotes the formation of reactive oxygen species (ROS), which react with and alter the functions of biomolecules. Moreover, there is no regulated iron excretion mechanism from our body. Hence, iron homeostasis is tightly regulated by the hormone hepcidin that restricts iron absorption and controls iron distribution in the bod...

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Department:
MRC Weatherall Institute of Molecular Medicine, Human Immunology Unit
Role:
Author

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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