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Interactions between the Nrf2 antioxidant response and mammalian iron homeostasis

Abstract:

Iron is an essential micronutrient as it contributes to the oxygen-carrying capacity of blood and is a cofactor for many enzymes. However, excess iron is toxic as it promotes the formation of reactive oxygen species (ROS), which react with and alter the functions of biomolecules. Moreover, there is no regulated iron excretion mechanism from our body. Hence, iron homeostasis is tightly regulated by the hormone hepcidin that restricts iron absorption and controls iron distribution in the bod...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author

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Role:
Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:c6516835-43c1-45bd-86b1-532116e36aa8
Deposit date:
2017-12-11

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