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Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue

Abstract:

Background
A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations. The aim of this study was to determine if these specific loci were associated with laboratory features of dengue that correlate with clinical severity with the aim of elucidating the functional basis of these genetic variants.

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12879-017-2514-6

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Grant:
097430/Z/11/Z; 084368/Z/07/Z
Genome Institute of Singapore More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Infectious Diseases Journal website
Volume:
17
Pages:
412
Publication date:
2017-06-09
Acceptance date:
2017-06-01
DOI:
EISSN:
1471-2334
Pubs id:
pubs:700547
URN:
uri:c64bffcf-8107-4d4e-9269-945de4fb2f98
UUID:
uuid:c64bffcf-8107-4d4e-9269-945de4fb2f98
Local pid:
pubs:700547
Language:
English
Keywords:

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