Evaluating evolutionary models of stress-induced mutagenesis in bacteria

Journal article

Increased mutation rates under stress allow bacterial populations to adapt rapidly to stressors, including antibiotics. Here we evaluate existing models for the evolution of stress-induced mutagenesis and present a new model arguing that it evolves as a result of a complex interplay between direct selection for increased stress tolerance, second-order selection for increased evolvability and genetic drift. Further progress in our understanding of the evolutionary biology of stress and mutagen...

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Authors: MacLean, R; Torres-Barceló, C; Moxon, R

• Journal: Nature Reviews Genetics
• Volume: 14
• Issue: 3
• Pages: 221-227
• Publication date: 2013-03-01
• DOI: 10.1038/nrg3415
• EISSN: 1471-0064
• ISSN: 1471-0056
• Language: English