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Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27.

Abstract:

The fine specificity of T cell recognition of peptide analogues of the influenza nucleoprotein epitope, NP 383-391 SRYWAIRTR, was studied using HLA B27-restricted influenza-specific cytotoxic T cell (CTL) clones, of defined T cell receptor (TcR) usage, derived from unrelated individuals following natural infection. Even conservative amino acid substitutions of the peptide residues P4, P7 and P8 influenced CTL recognition. These side chains are probably directly contacted by the TcR. CTL clone...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830241015

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, Experimental Medicine Division
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
European journal of immunology
Volume:
24
Issue:
10
Pages:
2357-2363
Publication date:
1994-10-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:c6406ee9-43c0-4eae-b172-18b68f9e8960
Source identifiers:
35613
Local pid:
pubs:35613

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